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Familial Mediterranean fever(FMF)is an inherited autosomal recessive disorder characterized by recurrent,self-limited attacks of fever and serosal inflammation[1-4].The disease is most commonly encountered in patients of Armenian,Jewish,and Arab origin,but has also been sporadically found in many other ethnic groups[4].In addition to the characteristic febrile paroxysms of peritonitis,pleuritis,and arthritis,a number of less common manifestations-namely,pericarditis,myalgia,bowel obstruction,renal disease,and a variety of cutaneous lesions-have been described.Meningeal involvement has not been widely recognized as a manifestation of FMF, although occasional reports of meningeal irritation,meningismus,and frank meningitis have appeared in the literature.The purpose of this report is to review the clinical and laboratory findings of the reported cases of meningitis allegedly associated with FMF and to describe the course of another patient extensively studied during several episodes. |
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